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The focus of our laboratory is to understand how DNA transactions such as transcription and DNA repair are accomplished in the context of chromatin. We are particularly interested in understanding how the Williams Syndrome Transcription Factor (WSTF), a subunit of several chromatin remodeling complexes, is involved in development, and how WSTF haploinsufficiency may contribute to the clinical profile of patients with Williams Syndrome. We are also interested in understanding how histone modifications are involved in DNA damage repair, and how nuclear genome stability and mitochondrial genome stability are interlinked.
Hui-Ching Kuo
LAB ALUMNI
Collaborators:
Craig Peterson UMass Medical School
Jonathan Henry University of Illinois Urbana
Mary Ann Osley UNM Health Sciences Center